Known to be responsible for the appetite suppressing activity of hoodia gordonii, a dietary supplement used for weight loss.
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Hoodia gordonii is a low-growing succulent South American plant easily recognized by its projecting spines and the aroma of its flowers, which smell like spoiled meat. For centuries, this plant has been used locally as an appetite suppressant. According to the South African Council for Scientific and Industrial Research, the active ingredient in the plant is an oxypregnane steroidal glycoside dubbed P57AS3, or simply P57.
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Thus far, there have not been any reports in the medical literature regarding significant hoodia side effect but high dosages could lead to an increase in blood pressure and heart rate.
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